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<title>Membrane stabilizing effect</title>
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<span id="openzim-page-title" class="mw-page-title-main"><span class="mw-page-title-main">Membrane stabilizing effect</span></span>
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<p><b>Membrane stabilizing effects</b> involve the inhibition or total abolishing of <a href="Action_potentials" class="mw-redirect" title="Action potentials">action potentials</a> from being propagated across the membrane. This phenomenon is common in nerve tissues as they are the carrier of impulses from the periphery to the <a href="Central_nervous_system" title="Central nervous system">central nervous system</a>. Membrane stabilization is the method through which <a href="Local_anesthetic" title="Local anesthetic">local anesthetics</a> work. They block the propagation of action potentials across nerve cells, thereby producing a nerve block.
</p><p>Some <a href="Beta-blockers" class="mw-redirect" title="Beta-blockers">beta-blockers</a> also possess what is referred to as membrane stabilizing activity (MSA). This effect is similar to the membrane stabilizing activity of <a href="Sodium_channel_blockers" class="mw-redirect" title="Sodium channel blockers">sodium channel blockers</a> that represent <a href="Class_I_antiarrhythmic" class="mw-redirect" title="Class I antiarrhythmic">Class I antiarrhythmics</a>. MSA agents produced by beta-blockers reduce the increase of cardiac action potential, while also leading to other electrophysiological effects. However, MSA occurs only at very high concentrations and is not of clinical relevance, except after large doses of MSA compounds.<sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup>
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<div class="mw-heading mw-heading2"><h2 id="References">References</h2></div>
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</style><cite id="CITEREFAronson2008" class="citation journal cs1">Aronson, JK (2008). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2418988">"Changing beta-blockers in heart failure: when is a class not a class?"</a>. <i>The British Journal of General Practice</i>. <b>58</b> (551): <span class="nowrap">387–</span>389. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.3399%2Fbjgp08X299317">10.3399/bjgp08X299317</a>. <a href="PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2418988">2418988</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/18505613">18505613</a>.</cite></span>
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